Journal article
Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review
AW Bartlett, MP Cann, DK Yeoh, A Bernard, AL Ryan, CC Blyth, RS Kotecha, BJ McMullan, AS Moore, GM Haeusler, JE Clark
Pediatric Blood and Cancer | WILEY | Published : 2019
DOI: 10.1002/pbc.27564
Abstract
Background: A thorough understanding of local and contemporary invasive fungal infection (IFI) epidemiology in immunocompromised children is required to provide a rationale for targeted prevention and treatment strategies. Methods: Retrospective data over 10 years from four tertiary pediatric oncology and hematopoietic stem cell transplant (HSCT) units across Australia were analyzed to report demographic, clinical, and mycological characteristics of IFI episodes, and crude IFI prevalence in select oncology/HSCT groups. Kaplan–Meier survival analyses were used to calculate 180-day overall survival. Results: A total of 337 IFI episodes occurred in 320 children, of which 149 (44.2%), 51 (15.1%)..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
[ "Research nurses Katrina Anderson and Zoe Allaway extracted and entered data for Brisbane and Melbourne sites. Rishi S. Kotecha is supported by an NHMRC Fellowship (2018-2021; APP1142627). Andrew S. Moore was supported by a Children's Hospital Foundation Fellowship (2012-2017) and an NHMRC Early Career Fellowship (2012-2016). Christopher C. Blyth is supported by an NHMRC Career development Fellowship (2016-2019). Gabrielle M. Haeusler was supported by an NHMRC postgraduate scholarship (GNT1056158).", "We thank Sharon Chen, Monica Slavin, and the Australian and New Zealand Mycology Interest Group for sharing the case report form from their study (23). The study network was developed under the auspices of the Australian and New Zealand Paediatric Infectious Diseases Group (ANZPID) to initiate this multicenter retrospective cohort study; Exploring the Epidemiology and Risk Factors for Invasive Fungal Infections (IFIs) in Immunocompromised Children (TERIFIC)." ]